个人简介

徐鉴，浙江金华人

2014-2019  浙江大学  化学 博士

联系方式

Email：jianxu@zjut.edu.cn

课题组主页

https://www.x-mol.com/groups/xujian

代表性论文论著

第一作者及通讯作者文章

1. J. Xu, Y.X. Cen, W. Singh, J. Fan, L. Wu, X.F. Lin, J.H. Zhou*, M. Huang*, M. T. Reetz*, & Q. Wu*, Stereodivergent Protein Engineering of a Lipase to Access All Possible Stereoisomers of Chiral Esters with Two Stereo-centers, J. Am. Chem. Soc. 2019, (141), 7934-7945.

2. J. Xu, Y. Hu, J. Fan, M. Arkin, D. Li, Y. Peng, W. Xu, X. Lin & Q. Wu*, Light-Driven Kinetic Resolution of α-Functionalized Carboxylic Acids Enabled by Engineered Fatty Acid Photodecarboxylase, Angew. Chem. Int. Edit. 2019, (58), 8474-8478.

3. J Xu, Y.Z Peng, Z.G Wang, Y.J Hu, J.J Fan, H Zheng, X.F Lin, Q Wu*, Exploiting Cofactor Versatility to Convert a FAD Dependent Baeyer?Villiger Monooxygenase into a Ketoreductase, Angew. Chem. Int. Edit. 2019, (59), 14499-14503.

4. J. Xu, M. Arkin, Y. Z Peng, W. H Xu, H. L. Yu, X. F. Lin and Q. Wu*, Enantiocomplementary Decarboxylative Hydroxylation Combining Photocatalysis and Whole-Cell Biocatalysis in a One-pot Cascade Process, Green. Chem. 2019, (21), 1907-1911.

5. B Xia, J. Xu, Z. W. Xiang, Y. X. Cen, Y. J. Hu, X. F. Lin, Q. Wu*, Stereoselectivity-Tailored, Metal-Free Hydrolytic Dynamic Kinetic Resolution of Morita-Baylis-Hillman Acetates Using an Engineered Lipase-Organic Base Cocatalyst. ACS Catal. 2017, 7 (7), 4542-4549. Co-first author.

6. Enantiocomplementary C–H Bond Hydroxylation Combining Photo-Catalysis and Whole-Cell Biocatalysis in a One-Pot Cascade Process. Y.Z Peng, D.Y Li, J.J Fan, W. H Xu, J Xu,* H .L Yu, X.F Li, and Q Wu*. Eur. J. Org. Chem. 2020, 821–825. Corresponding author.

7. J. J Fan, Y.Z Peng, W. H Xu, A. L Wang, J. Xu*, H. L Yu, X. F Lin and Q. Wu*, Double Enzyme-catalyzed One-Pot Synthesis of Enantiocomplementary Vicinal Fluoro Alcohols. Org. Lett. 2020, 22, 14, 5446–5450. Corresponding author.

8. F. Xu, J. Xu, Y. J. Hu, X. F. Lin, Q. Wu*, One-pot bienzymatic cascade combining decarboxylative aldol reaction and kinetic resolution to synthesize chiral beta-hydroxy ketone derivatives. RSC Adv. 2016, 6 (80), 76829-76837. Co-first author.

主要研究项目

1.酶催化多功能性的发现，创造多种自然界中不存在的酶催化功能；

2.定向进化调控酶的立体选择性、稳定性。