个人简介

  张晓健，博士，讲师，河北衡水人。主要从事手性医药中间体的生物合成方面研究。近年来主持国家重点研发计划子课题、浙江省公益应用项目、企业横向合作项目多项。在Bioresource Technology、Journal of Agricultural and Food Chemistry等相关领域知名期刊发表多篇论文。

联系方式

Email：xjzhang020@zjut.edu.cn

电话：0731-88320379

代表性论文论著

1. Zhang Xiao-Jian; Wang Wen?Zhong; Zhou Rong; Liu Zhi-Qiang*, Zheng Yu-Guo. Asymmetric synthesis of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate using a self-sufficient biocatalyst based on carbonyl reductase and cofactor co-immobilization, Bioprocess and Biosystems Engineering, 2019, 43: 20-31. (JCR2区，IF 2.3)

2. Zhanng Xiao-Jian; Zheng Ling; Wu Di; Zhou Rong; Liu Zhi-Qiang*, Zheng Yu-Guo. Production of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate using carbonyl reductase coupled with glucose dehydrogenase with high space-time yield, Biotechnology Progress, 2019, 36(1): 0-UNSP e2900. (JCR2区，IF 2.4)

3. Zhang Xiao-Jian; Fan Hao Hao; Liu Nan; Wang Xin Xin; Cheng Feng; Liu Zhi-Qiang*; Zheng Yu-Guo; A novel self-sufficient biocatalyst based on transaminase and pyridoxal 5 '-phosphate covalent co-immobilization and its application in continuous biosynthesis of sitagliptin, Enzyme and Microbial Technology, 2019, 130: 0-UNSP 109362. (JCR2区，IF 3.5)

主要研究项目

1. 国家重点研发项目子课题:兰卡杀菌素等聚酮类抗生素的碳链延长反应解析（2019YFA0905000）

2. 浙江省科技计划项目-公益技术: 高效立体选择性卤醇脱卤酶催化合成手性环氧氯丙烷（2016C31013）