个人简介
陈小龙， 博士、博导、浙工大资深教授，浙工大发酵工程研究所所长，第三批国家“万人计划”科技领军人才和浙江省“新世纪”151第一层次人才。主要研究方向：生物产品的发酵和结构修饰。承担的项目：主持国家自然科学基金、浙江省科技厅重大专项、浙江省自然科学基金、浙江省教育厅等项目8项，负责企业横向项目20余项；作为主要参加者参加国家973项目、国家863项目、国家自然科学基金项目、国家十五攻关项目、浙江省科技厅重大项目等20余项。主要成果：获得国家科技发明二等奖、浙江省科学技术一等奖、中石化科技发明一等奖、浙江省高校成果一等奖等奖项。申请国家发明专利20余项，其中授权15项。主要代表性论文论著：在“Bioresource Technology”、“Journal of Agricultural and Food Chemistry”、“Journal of Pesticide Science”、“Journal of Pest Science”、“The Journal of Antibiotics”、“Biotechnology and Bioprocess Engineering”、“Chemical Reviews”、“Current Medicinal Chemistry”、“Journal of Chromatography B”、“Biotechnology Progress”、“Journal of Biotechnology”等国内外著名杂志上发表论文100多篇。2017年发表英文专著1部。
联系方式
Email：richard_chen@zjut.edu.cn
电话：0571-88320571
主要奖励和荣誉
国家“万人计划”科技创新领军人才（2018）
浙江省优秀教师（2018）
浙江省高校优秀共产党员（2016）；
浙江省万人好党员（2016）；
台州市500精英人才（2015）；
浙江省“新世纪”151第一层次人才（2008）；
2008年获得国家科技发明二等奖1项(3/5)；
2007年获得浙江省科学技术一等奖1项（3/11）、中国石化协会技术发明一等奖1项（3/5）；
2006年获得浙江省高校成果一等奖1项(1/5)、二等奖1项（3/5）；
代表性论文论著
1. Chen, H. C., Cai, X. Q., Xu, A. J., Zhu, L. J., Lu, Y. L., Chen, X. L.*, & Liu, S. J. (2019). Characterization of Glucokinase Catalysis from a Pseudo-Dimeric View. Applied Biochemistry and Biotechnology, 189(2), 345-358. doi: 10.1007/s12010-019-02998-z
2. Chen, H. C., Qu, X. L., Liu, N., Wang, S. F., Chen, X. L.*, & Liu, S. J. (2018). Study of the adsorption process of heavy metals cations on Kraft lignin. Chemical Engineering Research & Design, 139, 248-258. doi: 10.1016/j.cherd.2018.09.028
3. Fan, Y. X., Lu, Y. L., Chen, X. L.*, Tekwani, B., Li, X. C., & Shen, Y. C. (2018). Anti-Leishmanial and Cytotoxic Activities of a Series of Maleimides: Synthesis, Biological Evaluation and Structure-Activity Relationship. Molecules, 23(11). doi: 10.3390/molecules23112878
4. Zhang, D., Lu, Y. L., Chen, H. C., Wu, C. T., Zhang, H., Chen, L. Y., & Chen, X. L*. (2020). Antifungal peptides produced by actinomycetes and their biological activities against plant diseases. Journal of Antibiotics, 73(5), 265-282. doi: 10.1038/s41429-020-0287-4
5. Zhu, L. J., Jiang, D., Zhou, Y. Y., Lu, Y. L., Fan, Y. X., & Chen, X. L.* (2019). Batch-feeding whole-cell catalytic synthesis of -arbutin by amylosucrase from Xanthomonas campestris. Journal of Industrial Microbiology & Biotechnology, 46(6), 759-767. doi: 10.1007/s10295-019-02143-z
6. Zhu, L. J., Xu, M., Lu, C. X., Chen, L. Y., Xu, A. J., Fang, J. Y., Chen, X. L.* (2019). Optimization of whole-cell biotransformation for scale-up production of -arbutin from hydroquinone by the use of recombinant Escherichia coli. Amb Express, 9. doi: 10.1186/s13568-019-0820-7
7. Lu Yuele, Chen Xiaolong*. Stereoselective Behavior of the Chiral Herbicides Diclofop-Methyl andDiclofop During the Soy Sauce Brewing Process. Chirality, 2016, 28: 78-84;
8. Lu Yuele, Chen Xiaolong*. Stereoselective Behavior of Fungicide Benalaxyl during Grape Growth andWine-making Process. Chirality, 2016, 28: 394-398.
9. Xiao-Long Chen*, Li-Jun Zhang, Fu-Ge Li,Yong-Xian Fan, Wei-Ping Wang, Bao-Ju Li and Yin-Chu Shen. Synthesis and antifungal evaluation of a series of maleimides. Pest Management Science, 2015，71: 433-440.
10. Chen Xiaolong *; LuoXinrong ; Cao Feifei ;Zhu Ting heng. Molecularcloning, expression of CPR gene from Rhizopus oryzae into Rhizopus nigericansand its application in the 11 alpha-hydroxylation of 16 alpha,17-epoxy-progesterone Enzyme andMicrobial Technology, 2014, 66: 28-34.
11. Zhenzhong Shen, Yongxian Fan, Fuge Li, Xiaolong Chen*, Yinchu Shen. Synthesis of a series of N-substituted dimethylmaleimides and their antifungal activities against Sclerotinia sclerotiorum. Journal of Pest Science, 2013,86, 363-360.
12. Yongxian Fan, Yang Yu, Xiaoqing Jia, Xiaolong Chen*, Yinchu Shen. Cloning, expression and medium optimization of validamycin glycosyltransferase from Streptomyces hygroscopicus var. jinggangensis for the biotransformation of validoxylamine A to produce validamycin A using free resting cells. Bioresource Technology, 2013,131: 13-20.
13. Rui Guo, Yongxian Fan, Xiaolong Chen*, Yinchu Shen. Chiral resolution of racemic p-methylsulfonylphenyl serine ethyl ester with lipases: The mechanism of side reaction and its suppression. Journal of Agricultural and Food Chemistry, 2013, 61: 152-166.
14. Wei Li, Yongxian Fan, Zhenzhong Shen, Xiaolong Chen*, Yinchu Shen. Antifungal activity of simple compounds with maleic anhydride or dimethylmaleimide structure against Botrytis cinerea. Journal of Pesticide Science, 2012, 37: 1-5.
15. Xiaolong Chen, Xiaohui Zhu, Yicheng Ding, Yinchu Shen. Antifungal activity of tautomycin and related compounds against Sclerotinia sclerotiorum. The Journal of Antibiotics, 2011, 64: 563-569.
16. Xiao-Long Chen, Yu-Hua Xu, Yu-Guo Zheng, and Yin-Chu Shen. 2010. Improvement of tautomycin production with Streptomyces spiroverticillatus by feeding glucose and maleic anhydride. Biotechnology and Bioprocess Engineering, 15: 969-974.
17. Xiaolong Chen, Yuguo Zheng, Yinchu Shen.Bioassay method for the quantitative determination of tautomycin in the fermentation broth with Sclerotinia sclerotiorum. Journal of Rapid Methods and Automation in Microbiology, 2008, 16: 199-209.
18．Xiaolong Chen, Yuguo Zheng, Yinchu Shen.Natural Products with Maleic Anhydride Structure: Nonadrides, Tautomycin, Chaetomellic Anhydride and Other Compounds. Chemical Reviews 2007, 107: 1777-1830.
19.Xiaolong Chen, Yuguo Zheng, Yinchu Shen. Voglibose (Basen (R) AO-128), one of the most important alpha-glucosidase inhibitors. Current Medicinal Chemistry 2006, 13: 109-116.
20．Xiaolong Chen, Yongxian Fan, Yuguo Zheng and Yinchu Shen. Properties and production of valienamine and its related analogues. Chemical Reviews, 2003, 103: 1955-1977.
21．Xiaolong Chen, Yuguo Zheng and Yinchu Shen. A new method for the production of valienamine with microbial degradation of acarbose. Biotechnology Progress, 2005, 21: 1002-1003.
22．Xiaolong Chen, Yuguo Zheng and Yinchu Shen. Quantitative analysis of valienamine in the microbial degradation of validamycin A after derivation with p-nitrofluorobenzene by reversed-phase high-performance liquid chromatography. Journal of Chromatography B, 2005 824: 341-347.
国内外著名杂志上发表论文150多篇。
专著
陈小龙，陆跃乐，范永仙，沈寅初. Validamycin and its derivatives- Discovery, chemical synthesis, and biological activity. Elsevier, 2017.4.
发明专利
1. 顺丁烯二酸酯化合物在制备油菜菌核病菌抑菌剂中的应用，ZL201010122276.9，1/5
2. 顺丁烯二酸酯类化合物对油菜菌核病菌的抑制，ZL201010122683.X，1/5
3. 顺丁烯二酸酐类化合物在抗灰霉病方面的应用，ZL201010122309.X，1/5
4. 一种提高变构霉素发酵产量的制备方法，ZL201010199312.1，1/5
5. 一种变构酸的制备方法，ZL201010178819.8，1/5
6. 一种顺丁烯二酰亚胺类化合物及其制备与应用，ZL201110249201.1，1/5
N-(3,5-二氯苯基)-3,4-二氯-顺丁烯二酰亚胺在抗真菌感染中的应用，ZL201310462766.7，1/5
7. G6PDH基因在提高黑根霉对甾体C11α-羟基化能力中的应用及菌株，ZL201310505530.7，1/5
8. 一种3,4-二氯顺丁烯二酰亚胺化合物及其制备与应用，ZL201310047509.7，2/5
主要研究项目
1. 国家自然科学基金项目“基因组学法研究马来酰亚胺类化合物抗Sclerotinia sclerotiorum机制及作用靶标酶”
2. 浙江省科学厅重大专项（2012C12003-1）“产糖基转移酶基因工程菌株的构建及其在生物催化法生产井冈霉素A中的应用”
3．国家自然科学基金项目（21172198）"基于变构霉素含顺丁烯二酸酐片段的化合物衍生、优化及其抗菌核病菌活性研究"
4. 浙江省科学厅重大专项（2007C12088）“顺丁烯二酸酐结构先导物生物合成及农药活性化合物创制”
5．浙江自然科学基金项目（编号M303049）“腺苷蛋氨酸合成酶的基因克隆及其酶学特性研究”
主持企业横向项目30余项。