个人简介
吴哲明,浙江浦江人,讲师。主要研究领域为生物催化与生物转化及酶工程等。作为第一作者在Biotechnol. Adv., Process Biochem, Appl. Microbiol. Biot等知名期刊发表SCI、EI收录论文6篇,授权中国发明专利4件。主持国家自然科学基金、浙江省自然科学基金、浙江省博士后择优资助项目等项目3项。
联系方式
Email:wuzheming@zjut.edu.cn
主要奖励和荣誉
1. 浙江工业大学优秀博士学位论文
2. 浙江工业大学第十二届青年教师教学技能竞赛优胜奖
代表性论文论著
1.Wu ZM; Liu CF; Zhang ZY; Zheng RC*; Zheng YG, Amidase as a versatile tool in amide-bond cleavage: From molecular features to biotechnological applications. Biotechnology advances, 2020,https://doi.org/10.1016/j.biotechadv.2020.107574.
2.Wu ZM; Hao CL; Tong T; Zheng RC*, Zheng YG, Purification of (S)-3-cyano-5-methylhexanoic acid from bioconversion broth using an acetone/ammonium sulfate aqueous two-phase system, Process Biochemistry, 2020, 89: 186-192
3. Wu ZM; Zheng RC; Tang XL; Zheng YG *, Identification and characterization of a thermostable and cobalt-dependent amidase from Burkholderia phytofirmans ZJB-15079 for efficient synthesis of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid, Applied Microbiology and Biotechnology, 2017, 101(5): 1953-1964
4. Wu ZM; Zheng RC; Zheng YG *, Exploitation and characterization of three versatile amidase super family members from Delftia tsuruhatensis ZJB-05174, Enzyme and Microbial Technology, 2016, 86: 93-102
5. Wu ZM; Zheng RC;; Ding X; Jin JQ; Zheng YG *, Enzymatic production of key intermediate of gabapentin by recombinant amidase from Pantoea sp. with high ratio of substrate to biocatalyst, Process Biochemistry, 2016, 51(5): 607-613.
发明专利
1. 一种来源于葡萄藤伯克氏菌的酰胺酶、基因、菌株及其应用. ZL201610528359.5.(郑仁朝,郑裕国,吴哲明)
2. 一种泛生菌酰胺酶、基因、载体、工程菌及其应用. ZL201510729058.4(郑仁朝,郑裕国,吴哲明)
3. 重组酰胺酶Dt-Ami 2、编码基因、载体、工程菌及应用. ZL201410481925.2(郑裕国,吴哲明,郑仁朝,沈寅初)
4. 重组酰胺酶Dt-Ami 7、编码基因、载体、工程菌及应用. ZL201410481953.4(郑裕国,郑仁朝,吴哲明,沈寅初)
主要研究项目
1. 国家自然科学基金/青年项目(主持). 酰胺酶标签结构域与其立体选择性的构效关系解析及理性设计.
2. 浙江省自然科学基金(主持). 半理性设计改造标签家族酰胺酶立体选择性的研究.