个人简介
翁春跃,男,博士,讲师。2015年6月于美国贝克曼研究中心获得生物科学与生物医学专业博士学位。主要研究方向为通过生物大数据分析解析微生物代谢产物高产机理,通过基因编辑技术完成微生物细胞工厂遗传改造,实现药用蛋白及工业酶制剂高效表达、代谢产物合成途径优化等;关键医药中间体的酶法合成。主持浙江省自然科学基金1项,参与国家自然科学基金等国家级项目。发表研究论文9篇,申请发明专利3项。
联系方式
Email:cweng@zjut.edu.cn
电话:0571-88320391
代表性论文论著
1. Chun-Yue Weng, Mo-Han Zhu, Zhi-Qiang Liu, Yu-Guo Zheng*. Integrated bioinformatics analyses identified SCL3-induced regulatory network in Arabidopsis thaliana roots. Biotechnology Letters, 2020:1-15.
2. Chun-Yue Weng, Xin-Yi Hu, Ya-Jun Wang*. Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. 3 biotech, 2020; 10(3):1-19.
3. Chun-Yue Weng, Dan-Na Wang, Shan-Yun Ban, Qiu-Yao Zhai, Xin-Yi Hu, Feng Cheng, Ya-Jun Wang*, Yu-Guo Zheng. One-step eantioselective bioresolution for (S)-2-chlorophenylglycine methyl ester catalyzed by the immobilized Protease 6SD on multi-walled carbon nanotubes in a triphasic system. Journal of Biotechnology, 2020 (Accepted).
4. Chun-Yue Weng, Li-Zhen Shi, Ya-Jun Wang*, Yu-Guo Zheng. Transcriptome analysis of Actinoplanes utahensis reveals molecular signature of saccharide impact on acarbose biosynthesis. 3 biotech, 2020; https://doi.org/10.1007/s13205-020-02466-0 (Accepted).
5. Chun-Yue Weng, Tung Nguyen, John Shively*. miRNA-342 regulates CEACAM1-induced lumen formation in a 3D model of mammary gland morphogenesis. Journal of Biological Chemistry, 2016; 291(32):16777-86.
6. Ying-Nan Cheng, Shuai Qiu, Feng Cheng, Chun-Yue Weng, Ya-Jun Wang, Yu-Guo Zheng*. Enhancing catalytic efficiency of an Actinoplanes utahensis echinocandin B deacylase through random mutagenesis and site-directed mutagenesis. Applied Biochemistry and Biotechnology, 2019:1-14.
7. Li-Qun Jin, Zhe-Wen Xu, Bo Zhang, Ming Yi, Chun-Yue Weng, Shan Lin, Hui Wu, Xiang-Tian Qin, Feng Xu, Yi Teng, Shui-Jin Yuan, Zhi-Qiang Liu, Yu-Guo Zheng. Genome sequencing and analysis of fungus Hirsutella sinensis isolated from Ophiocordyceps sinensis. AMB Express, 2020, 10(1): 1-19.
发明专利
1. 王亚军,邱帅,李树芳,程峰,翁春跃,郑裕国. 一种能实现碱基突变的pFC330-BEC质粒及其应用。授权国:中国,公开号:CN201910932502.0,公开日:2019年09月29日。
2. 王亚军,翁春跃,王丹娜,程峰,郑裕国. 一种(S)-邻氯苯甘氨酸甲酯酶法合成方法。授权国:中国,公开号:CN202010641943.8,公开日:2020年09月01日。
3. 王亚军,班善赟,程峰,翁春跃,郑裕国. 一种脂肪酶突变体及其在制备(S)-2-氯苯甘氨酸甲酯中的应用。授权国:中国,公开号:CN202010036222.4,公开日:2020年05月08日。
主要研究项目
1. 基因组及转录组分析解析犹他放线菌Actinoplanes utahensis ZJB-08196高产阿卡波糖机理
2. (S)-邻氯苯甘氨酸甲酯的酶法合成
3. 肿瘤微环境的多组学分析
4. 赤霉素菌渣生物处理技术开发及应用
5. 赤霉素生产菌株改良及发酵过程优化