靳远祥
作者:admin 来源: 发布日期:2020-12-07 浏览次数:4574

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个人简介

  靳远祥,男,教授,博导,学院生物资源与生物环保研究所所长,浙江省杰出青年基金获得者,教育部“生物净化与转化”创新团队骨干成员,教育部长三角绿色制药2011协同创新中心成员,中国环境诱变剂学会致突变专业委员会委员,省毒理学会生态毒理专业委员会委员。主持国家自然基金面上项目、青年基金、省杰出青年基金、省重点基金等多项项目,骨干参与国家重点基金、国家重点研发计划课题、973计划课题、国家基金面上等国家级项目多项。获浙江省“十一五”优秀自然基金项目1项,浙江省教育厅科研成果奖二等奖2项。以第一或通讯作者在环境毒理学领域重要期刊如Environ Sci Technol, J Hazard Mater, Environ Int, Toxicol Sci, Environ Pollut, Sci Total Environ, Chem Res Toxicol等上发表SCI论文80余篇,其中2篇论文入选ESI热点论文,15篇论文入选ESI高被引论文,发表的论文被Web of Science核心合集数据库论文引用3300余次,个人H指数为33;谷歌学术引用4400余次,个人H指数40。另有8篇第一和通讯作者论文分别入选Environ Pollut, Chemosphere, Fish Shellfish Immunol等杂志的“Most Download Articles”和“Most Cited Articles”论文。担任Environ Sci Technol, J Hazard Mater, Environ Int, Toxicol Sci, Environ Pollut, Sci Total Environ, Chemosphere, Environ Sci Technol Lett等十余种环境和毒理学领域主流杂志的审稿人。关于农药、微塑料等污染物的毒理和风险评价的相关的研究成果被多次被“热心肠”、“微生态”公众号以及浙江科技新闻网、浙江在线等媒体报道。

 

联系方式

Email:jinyx@zjut.edu.cn

电话:0571-88320742

 

主要奖励和荣誉

1. 浙江大学包氏奖学金,2016年

2. 浙江省杰出青年基金获得者,2015年

3. 浙江省本科高校中青年学科带头人培养对象,2013年

4. 浙江工业大学骨干教师计划,2007年

5. 浙江省"151"第三层次人才,2005年

 

代表性论文论著(近5年)

1. Cuiyuan Jin, Xianling Yuan, Caiyun Wang, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Maternal exposure to imazalil disrupts intestinal barrier and bile acids enterohepatic circulation tightly related IL-22 expression in F0, F1 and F2 generations of mice. Journal of Hazardous Materials. 2021, 403, 123668 

2. Guiling Yang, Xianling Yuan, Cuiyuan Jin, Dou Wang, Yanhua Wang*, Wenyu Miao, Yuanxiang Jin (靳远祥)*. Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice. Environmental Pollution. 2020, 266, 115290 (工大100论文)

3. Zhiwei Bao, Yao Zhao, Anyi Wu, Ze Lou, Huahui Lu, Qianxuan Yu, Zhengwei Fu, Yuanxiang Jin (靳远祥) *. Sub-chronic carbendazim exposure induces hepatic glycolipid metabolism disorder accompanied by gut microbiota dysbiosis in adult zebrafish (Daino rerio). Science of the Total Environment. 2020, 739:140081 (工大100论文)

4. Huilin Yang, Hong Lai, Jing Huang, Liwei Sun, Jan Alexander Mennigen, Qiyu Wang, Yu Liu, Yuanxiang Jin (靳远祥) **, Wenqing Tu*. Polystyrene microplastics decrease Fe53B bioaccumulation but induce inflammatory stress in larval zebrafish. Chemosphere. 2020, 255: 127040

5. Wenyu Miao, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. 3-Methylcholanthrene alters the hepatic immune response in mice. Acta Biochim Biophys Sin (Shanghai). 2020, 52: 570-572     

6. Caiyun Wang, Yao Zhao, Yuanxiang Jin (靳远祥)*. The emerging PFOS alternative OBS exposure induced gut microbiota dysbiosis and hepatic metabolism disorder in adult zebrafish. Comparative Biochemistry and Physiology, Part C. 2020, 230:108703

7. Yao Zhao, Zhiwei Bao, Zhiqing Wan, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish. Science of the Total Environment. 2020, 710:136279  (工大100论文)

8. Huaping Tao, Zhiwei Bao, Cuiyuan Jin, Wenyu Miao, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Toxic effects and mechanisms of three commonly used fungicides on the human colon adenocarcinoma cell line Caco-2. Environmental Pollution. 2020, 263:114660  (工大100论文)

9. Xianling Yuan, Jiayan Shen, Xinyue Zhang, Wenqing Tu, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Imidacloprid disrupts the endocrine system by interacting with androgen receptor in male mice. Science of the Total Environment. 2020, 708: 135163   (工大100论文)

10. Luo T, Wang CY, Pan ZH, Jin CY, Fu ZW, Jin YX (靳远祥)*. Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring. Environmental Science & Technology. 2019, 53, 10978-10992   (工大100论文)

11. Luo T, Zhang Y, Wang CY, Wang XY, Zhou JJ, Shen ML, Zhao Y, Fu ZW, Jin YX (靳远祥)*. Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring. Environmental Pollution. 2019, 255:113122  (工大100论文)

12. Zihong Pan, Xianling Yuan, Wenqing Tu*, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Subchronic exposure of environmentally relevant concentrations of F-53B in mice resulted in gut barrier dysfunction and colonic inflammation in a sex-independent manner. Environmental Pollution. 2019, 253: 268-277   (工大100论文)

13. Caiyun Wang, Yi Zhang, Mi Deng, Xia Wang, Wenqing Tu*, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Bioaccumulation in the gut and liver causes gut barrier dysfunction and hepatic metabolism disorder in mice after exposure to low doses of OBS. Environment International. 2019, 129: 279-290      (工大100论文)

14. Xiaoyu Wang, Jiajie Zhou, Manlu Shen, Jiayan Shen, Xinyue Zhang, Yuanxiang Jin (靳远祥)*. Chlorpyrifos exposure induces lipid metabolism disorder at the physiological and transcriptomic levels in larval zebrafish. Acta Biochim Biophys Sin (Shanghai). 2019, 51:890-899    

15. Xianling Yuan, Zihong Pan, Cuiyuan Jin, Yinhua Ni, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Gut microbiota: an underestimated and unintended recipient for pesticide-induced toxicity. Chemosphere. 2019, 227: 425-434

16. Cuiyuan Jin, Rui Zhang, Yuanxiang Jin (靳远祥)*. Maternal exposure to imazalil disrupts the endocrine system in F1 generation mice. Molecular and Cellular Endocrinology. 2019, 486: 105-112 

17. Liang Lu, Ting Luo, Yao Zhao, Chunhui Cai, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Interaction between microplastics and microorganism as well as gut microbiota: A consideration on environmental animal and human health. Science of the Total Environment. 2019, 667:94-100   (工大100论文)

18. Ting Luo, Manlu Shen, Jiajie Zhou, Xiaoyu Wang, Jizhou Xia, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Chronic exposure to low doses of Pb induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels of mice. Environmental Toxicology. 2019, 34:521-529

19. Zhiqin Wan, Caiyun Wang, Jiajie Zhou, Manlu Shen, Xiaoyu Wang, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish. Chmosphere. 2019, 217: 646-658

20. Xiaoyu Wang, Manlu Shen, Jiajie Zhou, Yuanxiang Jin (靳远祥)*. Chlorpyrifos disturbs hepatic metabolism associated with oxidative stress and gut microbiota dysbiosis in adult zebrafish. Comparative Biochemistry and Physiology, Part C. 2019, 216: 19-28

21. Rui Zhang, Zihong Pan, Xiaoyu Wang, Manlu Shen, Jiajie Zhou, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Short-term propamocarb exposure induces hepatic metabolism disorder associated with gut microbiota dysbiosis in adult male zebrafish. Acta Biochim Biophys Sin (Shanghai). 2019, 51: 88-96

22. Yuanxiang Jin (靳远祥), Liang Lu, Wenqing Tu, Ting Luo, Zhengwei Fu. Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice. Science of the Total Environment. 2019, 649, 308-317      (工大100论文

23. Yi Zhang, Cuiyuan Jin, Xiaoyu Wang, Manlu Shen, Jiajie Zhou, Sisheng Wu, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice. Environmental Toxicology. 2019, 34:22-29

24. Cuiyuan Jin1, Zhaoyang Zeng1, Caiyun Wang, Ting Luo, Siyu Wang, Jicong Zhou, Yingchun Ni, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Insights into a possible mechanism underlying the connection of carbendazim-induced lipid metabolism disorder and gut microbiota dysbiosis in mice. Toxicological Sciences. 2018, 166(2): 382-393

25. Sisheng Wu, Ting Luo, Siyu Wang, Jicong Zhou, Yingchun Ni, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Chronic exposure to fungicide propamocarb induces bile acid metabolic disorder and increases trimethylamine in C57BL/6J mice. Science of the Total Environment. 2018, 642: 341-348     (工大100论文

26. Jizhou Xia, Liang Lu, Cuiyuan Jin, Siyu Wang, Jicong Zhou, Yingchun Ni, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Effects of short term lead exposure on gut microbiota and hepatic metabolism in adult zebrafish. Comparative Biochemistry and Physiology-Part C: Toxicology & Pharmacology. 2018, 209: 1-8 

27. Liang Lu, Zhiqin Wan, Ting Luo, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice. Science of the Total Environment. 2018, 631-632: 449-458   (工大100论文

28. Jizhou Xia, Cuiyuan Jin, Zihong Pan, Liwei Sun, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Chronic exposure to low concentrations of lead induces metabolic disorder and dysbiosis of the gut microbiota in mice. Science of the Total Environment. 2018, 631-632: 439-448     (工大100论文

29. Cuiyuan Jin, Ting Luo, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical and transcriptomic levels. Environmental Toxicology. 2018, 33:650-658

30. Yuanxiang Jin (靳远祥), Jizhou Xia, Zihong Pan, Jiajing Yang, Wenchao Wang, Zhengwei Fu*. Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish. Environmental Pollution. 2018, 235: 322-329     (工大100论文

31. Sisheng Wu, Cuiyuan Jin, Yueyi Wang, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Exposure to the fungicide propamocarb causes gut microbiota dysbiosis and metabolic disorder in mice. Environmental Pollution. 2018, 237: 775-783  (工大100论文)

32. Cuiyuan Jin, Jizhou Xia, Sisheng Wu, Wenqing Tu, Zihong Pan, Zhengwei Fu, Yueyi Wang, Yuanxiang Jin (靳远祥)*. Insights into a possible influence on gut microbiota and intestinal barrier function during chronic exposure of mice to imazalil. Toxicological Sciences. 2018, 162, 113-123 

33. Cuiyuan Jin, Ting Luo, Zhihong Zhu, Zihong Pan, Jiajing Yang, Wenchao Wang, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Comparative Biochemistry and Physiology-Part C: Toxicology & Pharmacology. 2017, 202: 85-93

34. Yuanxiang Jin (靳远祥), Sisheng Wu, Zhaoyang Zeng, Zhengwei Fu*. Effects of environmental pollutants on gut microbiota. Environmental Pollution. 2017, 222: 1-9  (工大100论文

35. Zhenzhen Liu, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Immunotoxic effects of atrazine and its main metabolites at environmental relevant concentrations on larval zebrafish (Danio rerio). Chemosphere. 2017, 166: 212-220  

36. Yuanxiang Jin (靳远祥), Yan Wu, Zhaoyang Zeng, Cuiyuan Jin, Sisheng Wu, Yueyi Wang,  Zhengwei Fu*. Exposure to oral antibiotics induces gut microbiota dysbiosis associated with lipid metabolism dysfunction and low-grade inflammation in mice. Toxicological Sciences. 2016, 154:140-152 

37. Yuanxiang Jin (靳远祥), Guanliang Chen, Zhengwei Fu*. Effects of TBEP on the induction of oxidative stress and endocrine disruption in TM3 Leydig cells. Environmental Toxicology. 2016, 31: 1276-1286

38. Cuiiyuan Jin, Zhaoyang Zeng, Zhengwei Fu, Yuanxiang Jin (靳远祥)*. Oral imazalil exposure induces gut microbiota dysbiosis and colonic inflammation in mice. Chemosphere. 2016, 160: 349-358

39. Yuanxiang Jin (靳远), Zhang SB, Tao RH, Huang J, He XZ, Qu LY, Fu ZW*. Oral exposure of mice to cadmium (), chromium (VI) and their mixture induce oxidative- and endoplasmic reticulum-stress mediated apoptosis in the livers. Environmental Toxicology. 2016, 31: 693-705

40. Yuanxiang Jin (靳远祥), Zhu ZH, Wang YY, Yang EL, Feng XY, Fu ZW*. The fungicide imazalil induces developmental abnormalities and alters locomotor activity during early developmental stages in zebrafish. Chemosphere. 2016, 153, 455-461

41. Yuanxiang Jin (靳远祥), Liu L, Zhang SB, Tao B, Tao RH, He XZ, Qu LY, Huang J, Wang X, Fu ZW*. Chromium alters lipopolysaccharide-induced inflammatory responses both in vivo and in vitro. Chemosphere. 2016, 148, 436-443

42. Liu ZZ, Wang YY, Zhu ZH, Yang EL, Feng XY, Fu ZW, Yuanxiang Jin (靳远祥)*. Atrazine and its main metabolites alter the locomotor activity of larval zebrafish (Danio rerio). Chemosphere. 2016, 148, 163-170

43. Yuanxiang Jin (靳远祥), Liu L, Zhang SB, He RJ, Wu Y, Chen GL, Fu ZW*. Cadmium exposure to murine macrophages decreases their inflammatory responses and increases their oxidative stress. Chemosphere. 2016, 144: 168-175

 

发明专利

1. 缪文钰、靳远祥、傅正伟,一种用于筛选HGFR靶向抗体的ELISA试剂盒及应用,国家发明专利,申请中 

 

主要研究项目

1.基于对肠道微生态和屏障功能的影响研究新型全氟和多氟化合物对哺乳动物的毒性机理(LZ20B070002)、浙江省重点基金、2020/01-2023/12、主持

2. 环境微塑料暴露引起斑马鱼肠道菌群失调导致行为和代谢紊乱的机理研究(21777146)、国家自然科学基金面上项目、2018/01-2021/12、主持

3.基于肠道菌群和脂质代谢变化研究环境相关浓度三种典型杀菌剂的毒理机制(LR16B070002)、浙江省杰出青年基金、2016/01-2019/12、主持

4.基于组蛋白甲基化表观遗传修饰研究芳香烃受体介导的致癌分子毒机制(21277128)、国家自然科学基金面上项目、2013/01-2016/12、主持

5.微生物农药发现及其生态安全研究(2017YFD0200503)、国家重点研发计划课题、2017/01-2020/12、参加

 

其他

1. 承担研究生《现代生物学进展》等课程的教学工作,教学效果良好。

2. 培养毕业生获浙江工业大学优秀硕士论文2篇(缪文钰2014年、陈冠良2015年)

3. 指导研究生主持浙江省新苗计划2项(缪文钰等2013年、张松彬等2015年)

4. 指导学生获得浙江省挑战杯一等奖1项(王凌港等2013年)、三等奖2项(张松彬等2015年、吴嗣圣等2017年)

5. 指导研究生获国家奖学金13人次(王凌港2013年、张松彬2015年、刘珍珍2015年、曾昭阳2015年、罗婷2017年(硕士)、陆亮2017年、金萃媛2018年(博士)、罗婷2019年(博士)、王彩云2019年、潘紫虹2019年、袁仙玲2019和2020年、鲍志伟2020年)

6. 指导研究生获得浙江工业大学十佳学术之星(张松彬2015年)