个人简介

教授，博士生导师，现任生物工程学院 微生物与发酵工程研究所所长。兼任浙江省微生物学会副理事长、中国微生物学会环境微生物专业委员会委员，中国微生物学会微生物学教学工作委员会委员。浙江兰溪人。1993年获南京大学生物学专业理学硕士；2001年获得浙江大学生物化学工程专业博士学位；多所美国高校（Rensselaer Polytechnic Institute等）访问学者；2010年入选浙江省新世纪151人才工程第一层次培养人员。国家精品课程“微生物学”和浙江省精品课程“基因工程”负责人；长期从事应用和环境微生物方面的科学研究工作。主持国家自然科学基金面上项目3项、参与国家自然科学基金重点项目和浙江省重大科技攻关项目各1项、主持863项目子课题、浙江省自然科学基金等项目10余项，获浙江省科技进步二等奖和省高校科研成果二等奖各1项，在 Biotechnology and Bioengineering, Bioresource Technology, Carbohydrate polymers, Marine Drugs, Journal of  Hazard Materials, Briefs in Bioinformatics, Applied Microbiology and Biotechnology, Enzyme Microbial Technology, Plasmid, Molecular Omics等国内外刊物发表100余篇论文，SCI论文60余篇。主编出版《基因工程技术》和《基因工程技术实验指导》等教材，获授权国家发明专利10余项。

联系方式

Email：whzhong@zjut.edu.cn

电话：0571--88320739

主要奖励和荣誉

1.2006年入选浙江省新世纪151人才工程第二层次。

2.2010年入选浙江省新世纪151人才工程第一层次。

2.2016年浙江省高校“三育人”先进个人。

3.浙江省优秀教学成果奖二等奖（2005）

4.浙江工业大学优秀教学成果奖一等奖（2005,2012）

5.浙江工业大学优秀教学成果奖二等奖（2012,2019）

代表性论文论著

[1] Tengfei Liu, Jun Li, Lequan Qiu, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Combined genomic and transcriptomic analysis of Dibutyl phthalate metabolic pathway in Arthrobacter sp. ZJUTW, Biotechnology and Bioengineering, 2020, DOI:10.1002/bit.27524

[2] Jun Li, Mingjie Shen, Zeyu Chea, Fanda Pan, Yang Yang*, Ming Shu, Guoqing Chen, Yang Jiao, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Expression and functional identification of two homologous nicotine dehydrogenases, NicA2 and Nox, from Pseudomonas sp. JY-Q, Protein Expression and Purification, 2020, doi:10.1016/j.pep.2020.105767

[3] Cui Peiwu, Zhong Weihong,  Qin Yong,  Tao Fuping, Wang Wei,  Zhan Jixun. Characterization of two new aromatic amino acid lyases from  actinomycetes for highly efficient production of p-coumaric acid, Bioprocess and Biosystems Engineering, 2020, 43(7): 1287-1298

[4] Yunhai Shao, Yanxin Wang, Rui Zhao, Jianmen Chen, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Biotechnology progress for removal of indoor gaseous formaldehyde, Applied Microbiology and Biotechnology, 2020, 104(9): 3715-3727

[5] Marie Thérèse Bidja Abena, Tongtong Li, Weihong Zhong*, Changes in the diversity of soil microbial communities and enrichment of potential petroleum hydrocarbon degraders as a result of crude oil, diesel and gasoline contamination, 3 Biotech, 2020, 10:42, DOI: 10.1007/ s13205-019-2027-7

[6] Jin Weihua, Fang Qiufu, Jian, Di, Li Tongtong, Wei Bin, Su Jiadong, Zhang Wenjing, Zhang Zhongshan, Zhang Fuming, Linhardt Robert J., Wang, Hong, Zhong Weihong*, Structural characteristics and anti-complement activities of  polysaccharides from Sargassum hemiphyllum, Glycoconjugate Journal, 2020, 37(5): 553-563

[7] Weihua Jin, Hong Tang, Jinmei Zhang, Bin Wei, Jiadong Sun, Wenjing Zhang, Fuming Zhang, Hong Wang, Robert J. Linhardt, Weihong Zhong*, Structural analysis of a novel sulfated galacto-fuco-xylo-glucuronomannan from Sargassum fusiforme and its anti-lung cancer activity, International Journal of Biological Macromolecules, 2020, 149: 450-458

[8] 郑秀成, 陈泽裕, 陈国庆, 李骏, 钟卫鸿*, 烟草废弃物中难降解有机物的微生物降解研究进展, 微生物学报, 2020, accept

[9] Hui Zhang, Rui Zhao, Chaochao Huang, Jun Li, Yunhai Shao, Weihong Zhong*, Selectively faster nicotine biodegradation by genomic modified Pseudomonas sp. JY-Q in environment coexisting with glucose, Applied Microbiology and Biotechnology, 2019,103(1): 339-348

[10]  Weihua Jin, Wanli Wu, Hong Tang, Bin Wei, Hong Wang, Jiadong Sun, Wenjing Zhang, and Weihong Zhong*, Structure Analysis and Anti-Tumor and Anti-Angiogenic Activities of Sulfated Galactofucan Extracted from Sargassum thunbergii, Marine Drugs, 2019, 17, 52.

[11] Yunhai Shao?, Jun Li?, Yanxin Wang, Fengmei Yi, Yanan Zhang, Peiwu Cui, Weihong Zhong*, Comparative genomics and transcriptomicsinsights into the C1 metabolic model of a formaldehyde-degrading strain Methylobacterium sp. XJLW, Mol Omics, 2019, 15: 138-149

[12] Yunhai Shao, Yanxin Wang, Fengmei Yi, Yanan Zhang, Wangqian Liu, Chen Yang, HuiMeng, Peiwu Cui, WeihongZhong*, Gaseous formaldehyde degrading by Methylobacterium sp. XJLW, Applied biochemistry and Biotechnology, 2019, 15: 138-149

[13] Jun Li, Jie Wang, Shanshan Li,Fengmei Yi,JianXu，Ming Shu,MingjieShen, Yang Jiao, Feng Tao, Chengyun Zhu, Hui Zhang,Zhu Chengyun, Wang Jie, Zhang Hui, QianShulan, WeihongZhong*, Co-occurrence of functional modules derived from nicotine degrading gene clusters confers additive effects in Pseudomonas sp. JY-Q，Applied Microbiology and Biotechnology, 2019, 103: 4499-4510

[14] Marie Thérèse BidjaAbena, Naranjargal Sodbaatara, Tongtong Li, Narantuya Damdinsuren, Battsetseg Choidash, Weihong Zhong*, Crude oil biodegradation by newly isolated bacterial strains and their consortium under soil microcosm experiment, Applied Biochemistry and Biotechnology, 2019, 189:1223-1244

[15] Marie Thérèse Bidja Abena, Tongtong Li, Muhammad Naeem Shahc, Weihong Zhong*, Biodegradation of total petroleum hydrocarbons (TPH) in highly contaminated soils by natural attenuation and bioaugmentation, Chemosphere, 2019, 234: 864-874.

[16] Marie Thérèse Bidja Abena, NaranjargalSodbaatara, Tongtong Li, Narantuya Damdinsuren, Battsetseg Choidash, Weihong Zhong*, Crude oil biodegradation by newly isolated bacterial strains and their consortium under soil microcosm experiment, Applied Biochemistry and Biotechnology, 2019, 189(4):1223-1244

[17] Weihua Jin, Shuai Li, Bing Liu, Hong Tang, Di Jiang, Quanbin Zhang* and Weihong Zhong*, The structural features of sulfated heteropolysaccharide (ST-1) from Sargassumthunbergii and their neuroprotective activities, International Journal of Biological Macromolecules,2018,108: 307-313

[18] Weihua Jin, ShuaiLi, Jiale Chen, Bing Liu, JieLi, Xueliang Li, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Increased soluble heterologous expression of a rat brain 3-O-sulfotransferase 1--a key enzyme for heparin biosynthesis, Protein express and purification，2018,151:23-29

[19] Weihua Jin, Langlang Ren, Bing Liu, Genxiang Mao, Yizhong Bao, Quanbin Zhang* and Weihong Zhong*, The structural features of the sulfated glucuronomannan oligosaccharides (GMS) and their anti-oxidant activities, Marine drugs, 2018, 16(9): 291

[20] Jun Li, Shulan Qian, Lie Xiong, Chengyun Zhu, Ming Shu, Jie Wang, Yang Jiao, Houlong He, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Comparative genomics reveals specific genetic architectures in nicotine metabolism ofPseudomonas sp. JY-Q isolated from tobacco waste extracts, Frontiers in Microbiology, 2017, 8:2085.

[21] Haichan Huang, Xiaobo Liu, ShencongLv, Weihong Zhong*, Fuming Zhang, Robert J. Linhardt, Recombinant Escherichia coli K5 strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular polysaccharide, 2016, Applied Microbiology and Biotechnology,2016,100(18): 7877-7885

[22] Guowei Su, Linhong Li, Haichan Hang, Weihong Zhong*, Ping Yu, Fuming Zhang, Robert J. Linhardt, Production of a low molecular weight heparin production using recombinant glycuronidase, Carbohydrate Polymers, 2015,134:151-57 (Published :Dec-2015)  
[23] Huagui Liu, Houlong He, Changhe Cheng, Jinli Liu, Ming Shu*,Yang Jiao, Feng Tao, Weihong Zhong*, Diversity analysis of the bacterial community in tobacco waste extract during reconstituted tobacco process, Applied Microbiology and Biotechnology, 2015, 99(1):469–476
[24] Xuanzhen Li, Yan Wang, Shijin Wu, Lequan Qiu, Li Gu, Jingjing Li, Bao Zhang, Weihong Zhong*, Peculiarities of metabolism of anthracene and pyrene by laccase producing fungus Pycnoporus sanguineus H1, Biotechnology and Applied Biochemistry, 2014, 61(5): 549–554
[25] Lequn Qiu, Wenwen Chen, Li Zhong, Wanxin Wu, Shijin Wu, Jianmen Chen, Fuming Zhang, Weihong Zhong*, Formaldehyde biodegradation by immobilized Methylobacterium sp. XJLW cells in a three-phase fluidized bed reactor, Bioprocess and Biosystems Engineering, 2014, 37(7):1377–1384
[26] Haichan Huang, Yingying Zhao, Shencong Lv, Weihong Zhong*, Fuming Zhang, Robert J. Linhardt, Quantitation of heparosan with heparin lyase III and spectrophotometry, Analytical Biochemistry, 2014, 447:46-48
[27] Qiu Lequan, Chen Yang, Zhong Li, Wu Shijin, Zhong Weihong*, Purification and some properties of dibutyl phthalate esterase from Arthrobacter sp. ZJUTW, Journal of Pure and Applied Microbiology, 2013, 7(4): 3071-3076
[28] Lei Zhao, Chenjing Zhu, Yang Gao, Chang Wang, Xuanzhen Li, Ming Shu, Yuping Shi, Weihong Zhong*, Nicotine degradation enhancement by Pseudomonas stutzeri ZCJ during aging process of tobacco leaves, World Journal of Microbiology and Biotechnology, 2012, 28:2077-2086
[29] Min Wei, Zhuoyi Kong, Lei Zhao, Yansheng Li, Li Zhong, Xuanzhen Li, Weihong Zhong*, Construction of a native promoter-containing transposon vector for stable monitoring the denitrifying bacterium Pseudomonas stutzeri LYS-86 by chromosomal integrated gfp, Plasmid, 2012, 86:61-68
[30] Lequan Qiu, Hanbing Ding, Weijian Wang, Zhuoyi Kong, Xuanzhen Li, Yuping Shi, Weihong Zhong*, Coenzyme Q10 production by immobilized Sphingomonas sp. ZUTE03 with conversion-extraction coupled process in a three-phase fluidized bed reactor, Enzyme and Microbial Technology, 2012, 50: 137-142

最近发明专利

1.钟卫鸿,黄海婵,刘晓波,吕沈聪,一种waaR基因缺陷型细菌合成低分子量肝素前体的方法,专利号:ZL201610048483.1 (2019-2-1授权)
2.钟卫鸿,黄海婵,吕沈聪,赵颖颖.一种酶法快速定量检测heparosan的方法，专利号:ZL 201310050183.3 (2015-4-22授权)
3.钟卫鸿,金晶,邱乐泉,吴石金,钟莉等,高活性高耐受甲醛降解菌及其应用, 专利号:ZL 201010204536.7  (2012-6授权)
4.钟卫鸿,李烜桢,邱乐泉,玛丽,谢观莲,一株柴油降解酵母菌及其应用,专利号: ZL201310031715.9 (2014-8授权)

5.钟卫鸿,吴石金,黄海婵,邱乐泉,钟莉等.肝素酶II在解聚肝素前体制备低分子量肝素中的应用,专利号:ZL201210488626.2 (2014-11授权)

主要研究项目

1. 国家自然科学基金面上项目(主持), 假单胞菌JY-Q中尼古丁代谢同工簇功能和互作机制研究, 2020-2023

2. 国家自然科学基金面上项目(主持), 废烟叶水提液中葡萄糖对假单胞菌JY-Q尼古丁降解抑制机制及解除研究, 2017-2020

3. 国家自然科学基金面上项目(主持), 大肠杆菌K5产肝素前体heparosan代谢控制研究, 2011-2013

4. 国家自然科学基金重点项目(分项负责人),含硫有机废气生物净化的传质-反应过程强化基础研究,2020-2024

5. 基于烟草内源菌的生化技术及其工业应用研究, 企业委托项目, 2019-2022